Tuesday, November 27, 2012

The Golden 8 Tips To Lower Your Blood Pressure





While high blood pressure (also know as hypertension) is a serious health problem, there’s good news. No matter what your age or physical condition, there are things you can do to prevent high blood pressure.
The U.S. Department of Health and Human Services offers these 8 tips to help you prevent high blood pressure, or reduce your blood pressure if it’s already a problem.

Are you overweight? Lose weight:

Maintaining a healthy weight (see your doctor about this) will help prevent high blood pressure. Getting back to a healthy weight is not as hard as it sounds. You can start by limiting the portion size of your meals and snacks, and cut way back on high calorie foods. If you eat as many calories as you burn each day, you’ll maintain your weight. Eating fewer calories than you burn will help you lose weight. And losing weight will help lower your blood pressure.

When you plan meals, think of your heart:

Choose a diet that includes plenty of fruits and vegetables. Keep total fat low and avoid foods that are high in saturated fats and cholesterol. Having a healthy heart will help prevent blood pressure.

Eat less salt and sodium:

Salt and sodium can increase blood pressure, so it’s important to read food labels. The U.S. guidelines suggest limiting sodium intake to no more than 2,400 mg, or about 1 teaspoon of salt each day. If you eat canned, processed, and convenience foods, buy the brands that are lower in sodium.If you salt your food at the table, try using less, or none. It may take a little while to get used to the new flavors, but you may find that food tastes better when you use less salt. Fast food can contain a lot of sodium, so if you eat fast food choose items that are lower in salt and sodium. Reducing your salt intake will help to prevent high blood pressure.

If you drink alcohol, practice moderation:

The U.S. guidelines recommend that men have no more than 2 drinks per day, and women have no more than one alcoholic beverage per day.

Increase your physical activity:

Exercise is a key factor in preventing high blood pressure. If you get very little exercise now, start slowly and work your way up to at least 30 minutes of a moderate-level activity, such as brisk walking or bicycling, each day. If time is a factor, you’ll still benefit by breaking the 30 minute daily exercise periods into 10 or 15 minute sessions.

Stop smoking:

Research shows that smoking increases your chances of developing a heart disease, stroke, stroke, peripheral arterial disease, and several forms of cancer.


Talk with your doctor or health care professional:

Learn what your blood pressure reading means to your health, and if medication is recommended for you to treat or prevent high blood pressure.

If your doctor prescribes medication, take it:

It’s important to understand:
  • what your blood pressure medication is expected to do for you
  • how to take your medication, and when
  • if your blood pressure medication has any side effects
  • if the blood pressure medication is safe to take with any other prescriptions or vitamins you are already taking
If you have high blood pressure and treatment is prescribed, don’t be afraid to ask questions or get another medical opinion. Once you understand why you’re taking the medication, follow the recommended dose.
But the best way to treat high blood pressure is to prevent high blood pressure from becoming a problem. These 8 tips, plus advice from your health care provider, can help you keep your blood pressure at a healthy level.

Drug of Choice for Different Diseases



For MRSA Infection-Vancomycin
For Malaria in Pregnancy-Chloroquine

For Whooping Cough or Perteusis- Erythromycin
For Kawasaki disease-IV Ig
For Warferin Overdose-Vit-K
For Heparin Overdose-Protamine
For hairy Cell Leukemia-Cladirabine
For Multiple Myeloma- Melphalan
For CML-Imatinib
For Wegner's granulomatosis-Cyclophosphamide
For HOCM- Propranolol
For Delirium Tremens-Diazepam
For Drug Induced Parkinsonism-Benzhexol
For Diacumarol Poisoning-Vit-K
For Type-1 Lepra Reaction-Steroids
For Type- 2 Lepra Reaction-Thalidomide
For Allergic Contect Dermatitis-Steroids
For PSVT- 1st-Adenosine, 2nd-Verapamil, 3rd-Digoxin
For Z-E Syndrome- Proton Pump Inhibitor
For Chancroid-Cotrimoxazole
For Dermatitis Herpetiformis-Dapsone
For Spastic Type of Cerebral Palsy-Diazepam
For Herpis Simplex Keratitis-Trifluridine
For Herpes Simplex Orolabialis-Pancyclovir
For Neonatal Herpes Simplex-Acyclovir
For Pneumocystis carinii Pneumonia- CotrimoxazoleFor Nodulo Cystic Acne-Retinoic acid
For Trigeminal Neuralgia-Carbamezapine
For Actinomycosis-Penicillin
For Plague- Streptomycin
For Opioid Withdrawal- Methadone 2nd-Clonidine
For Alcohol Withdrawal- Chlordiazepoxide 2nd-Diazepam
For Post Herpetic Neuralgia- Fluphenazine
For WEST Syndrome-ACTH
For Diabetic Diarrhoea- Clonidine
For Lithium Induced Neuropathy-Amiloride

Saturday, November 10, 2012

Mechanical Cardiopulmonary Resuscitation



Lund University cardiac arrest System (LUCAS)

The latest AHA 2010 guidelines on CPR has changed it’s sequence from ABC to CAB and stressed on the importance of effective chest compression. While there are still many debates exist in this sequence as the ATLS protocol and Neonatal Resus Protocol still maintaining it’s ABC sequences, the message is clear that chest compression should be done as effective as possible in order for the patient to achieve Return of Spontaneous Circulation. (ROSC)
The AHA guidelines defines the High Quality and Effective CPR through the criteria of 1) Rate is at least 100 compression per minute, 2) Depth of compression is 2 inches/5 cm in adult and 1 ½ inches in infants, 3) Minimal interruption as possible and it should be less than 10 seconds, 4) Avoiding excessive hyperventilation, and 5) Allow the chest wall to fully recoil in between compression.
In order to achieve that, the guidelines suggest that the rescuer taking turn every two minutes in performing CPR in order to minimize fatigue, do not stop the CPR while attaching the AED machine until the rhythm is being analyzed and less than 10 seconds should be use in checking the pulse.
However, we as a human still bound to the weakness and inconsistencies despite of many measures that we take. Besides, other issue also arise like should we do the CPR in ambulance? Will it still be effective, remain as a high quality CPR and the most importantly, will it guarantee the safeness of the healthcare provider?  


Autopulse - load distributing band (LDB) CPR

While it is still relatively new in Malaysia, the usage of the mechanical CPR devices has actually being practices around the world for a long time. The history itself begin from research in 1960’s and continues until now. 
From my personal opinion, this invention is indeed a genius art despite of conflicting study result regarding the usage of this device. For me, this device is a practical practice especially in continuation of CPR in the ambulance or when the CPR providers are getting tired.
The Conchrane Review 2011 found that there is insufficient evidence from human RCT's to conclude that mechanical chest compression is associated with benefit or harm. Ong et al (2012) in their review of 88 articles identify 10 studies that meet their inclusion criteria and finally draw a conclusion that that there are insufficient evidence to support or refute the use of mechanical CPR devices in setting of out hospital cardiac arrest and during ambulance transport. They further add that there is some low quality evidence suggesting that mechanical CPR  can improve consistency and reduce interruptions in chest compression. However, there is no evidence that mechanical CPR devices improve survival, to the contrary they may worsen neurological outcome.
Furthermore, the cost of implementing this procedure is very expensive compared to the traditional CPR which is of course free of charge. Therefore, i think that the usage of this device should be justified in context of physician preferences for now until there is a well establish study on this aspect.
Reference
Steven C Brooks, Blair L Bigham, Laurie J Morrison, "Mechanical versus Manual Chest Compression for Cardiac Arrest", Conchrane Database, 2011
Ong et al, "Mechanical CPR Devices Compared to Manual CPR During Out-of-hospital Cardiac Arrest and Ambulance Transport: A Systemic Review", Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:39.

Types and Causes of Hydrocephalus







Types and Causes of Hydrocephalus
What is hydrocephalus?
The term hydrocephalus is derived from the Greek words "hydro" meaning water and "cephalus" meaning head. As its name implies, it is a condition in which the primary characteristic is excessive accumulation of fluid in the brain. Although hydrocephalus was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF) - a clear fluid surrounding the brain and spinal cord. The excessive accumulation of CSF results in an abnormal dilation of the spaces in the brain called ventricles. This dilation causes potentially harmful pressure on the tissues of the brain.
The ventricular system is made up of four ventricles connected by narrow pathways. Normally, CSF flows through the ventricles, exits into cisterns (closed spaces that serve as reservoirs) at the base of the brain, bathes the surfaces of the brain and spinal cord, and then is absorbed into the bloodstream.

CSF has three important life-sustaining functions: 1) to keep the brain tissue buoyant, acting as a cushion or "shock absorber"; 2) to act as the vehicle for delivering nutrients to the brain and removing waste; and 3) to flow between the cranium and spine to compensate for changes in intracranial blood volume (the amount of blood within the brain).

The balance between production and absorption of CSF is critically important. Ideally, the fluid is almost completely absorbed into the bloodstream as it circulates; however, there are circumstances which, when present, will prevent or disturb the production or absorption of CSF, or which will inhibit its normal flow. When this balance is disturbed, hydrocephalus is the result.

What are the different types of hydrocephalus?
Hydrocephalus may be congenital or acquired. Congenital hydrocephalus is present at birth, and may be caused by either environmental influences during fetal development or genetic predisposition. Acquired hydrocephalus develops at the time of birth or at some point afterward. This type of hydrocephalus can affect individuals of all ages and may be caused by injury or disease.
Hydrocephalus may also be communicating or non-communicating. Communicating hydrocephalus occurs when the flow of CSF is blocked after it exits from the ventricles. This form is called communicating because the CSF can still flow between the ventricles, which remain open. Non-communicating hydrocephalus - also called "obstructive" hydrocephalus - occurs when the flow of CSF is blocked along one or more of the narrow pathways connecting the ventricles. One of the most common causes of hydrocephalus is "aqueductal stenosis." In this case, hydrocephalus results from a narrowing of the aqueduct of Sylvius, a small passageway between the third and fourth ventricles in the middle of the brain. There are two other forms of hydrocephalus which do not fit distinctly into the categories mentioned above and primarily affect adults: hydrocephalus ex-vacuo and normal pressure hydrocephalus.

Hydrocephalus ex-vacuo occurs when there is damage to the brain caused by stroke or traumatic injury. In these cases, there may be actual shrinkage (atrophy or wasting) of brain tissue. Normal pressure hydrocephalus commonly occurs in the elderly and is characterized by many of the same symptoms associated with other conditions that occur more often in the elderly, such as memory loss, dementia, gait disorder, urinary incontinence, and a general slowing of activity.

Who gets this disorder?
Incidence and prevalence data are difficult to establish as there is no existing national registry or database of people with hydrocephalus and closely associated disorders; however, hydrocephalus is believed to affect approximately 1 in every 500 children. At present, most of these cases are diagnosed prenatally, at the time of delivery, or in early childhood. Advances in diagnostic imaging technology allow more accurate diagnoses in individuals with atypical presentations, including adults with conditions such as normal pressure hydrocephalus.
What causes hydrocephalus?
The causes of hydrocephalus are not all well understood. Hydrocephalus may result from genetic inheritance (aqueductal stenosis) or developmental disorders such as those associated with neural tube defects including spina bifida and encephalocele. Other possible causes include complications of premature birth such as intraventricular hemorrhage, diseases such as meningitis, tumors, traumatic head injury, or subarachnoid hemorrhage blocking the exit from the ventricles to the cisterns and eliminating the cisterns themselves.

9 Ways to Burn Fat



Everyone's metabolism naturally slows down with age. At 40, you could be burning 100 to 300 
fewer calories a day than you did at 30, says Pamela M. Peeke, M.D., author of Body for Life for Women and assistant professor of medicine at the University of Maryland in Baltimore. That can translate into a 10-25-pound weight gain in a year. But you can counteract that slowdown and boost your body's fat-burning capabilities by making just a few tweaks to your daily routine. The following strategies will help you bust out of a weight-loss plateau and burn even more fat.


:Take five

Do five minutes of exercise each morning. We all have a metabolic thermostat, called the 
metastat, that can be turned up or down, and morning is the best time to activate it. Each day, your metastat is waiting for signals to rev up, so the more signals you can send it, the better. Your best bet is a light, full-body activity like walking orpush-ups.


:Fuel up in the morning

Numerous studies have found that regular breakfast eaters are often leaner than breakfast skippers. "Your metabolism naturally slows at night, but you can jump-start it in the morning by eating breakfast," says Tammy Lakatos Shames, R.D., C.D.N., co-author of Fire Up Your Metabolism. And because both your activity level and metabolism decrease later in the day, it's a good idea to make breakfast or lunch your largest meal.


:Fill up on good grains

Whole grains such as brown rice, wheat germ, dark bread, whole-grain cereal, oatmeal and bran leave you feeling full because they take longer to digest than simple carbohydrates. In a study from The American Journal of Clinical Nutrition, researchers at Brigham and Women's Hospital and Harvard Medical School evaluated the dietary intake of more than 74,000 women for 12 years. Overall, women who regularly ate the most whole-grain foods — about 1.5 servings a day — gained less weight than women who ate the least.


:Pump yourself up

Muscle burns more calories than fat does, and decreased muscle mass can be one of the main 
reasons metabolism slows. Disuse can cause women to drop as much as 10 pounds of muscle between the ages of 30 and 50. Losing that much muscle means you'll burn 350 to 500 fewer calories a day. To build and maintain muscle mass, aim for two to three strength-training workouts a week. If you don't belong to a gym, try push-ups, squats, abdominal crunches and tricep dips off a chair.


:Power on with protein 

Add a little high-quality, lowfat protein, such as chicken, fish and egg whites, to your meals, and you'll help your body burn fat faster. "Because protein requires more energy to digest, it speeds up your metabolism, and protein is necessary to ensure against loss of muscle tissue," says Michael Thurmond, author of 6 Day Body Makeover.


:Get your vitamin "I"

That's "I" for intensity. You love to walk, but if that usually means strolling along at a snail's pace, your waistline will pay little attention. Instead, put intensity, or "vitamin I," into your stride. Pick up your pace so you're walking at 4 mph, or one mile per 15 minutes. Once you build up your cardiovascular fitness level, you can even alternate between walking and jogging. The key is to get your heart rate up and keep your workouts challenging.


:Say yes to yogurt

In a recent study from the International Journal of Obesity, women who ate three daily servings of lowfat yogurt lost 60 percent more fat than women who didn't. In another study, participants who ate three daily servings of dairy lost more than twice as much fat as those who ate less than that. "Calcium-rich diets reduce fat-producing enzymes and increase enzymes that break down fat," says Michael B. Zemel, Ph.D., lead author of both studies and director of the Nutrition Institute at the University of Tennessee in Knoxville. Eat three servings of lowfat dairy a day, like milk, yogurt and hard cheeses (Gouda, Cheddar and Monterey Jack).


:Get active after eating

Your body's metabolic rate increases 10 percent after eating, and just a few minutes of activity could double that boost for up to three hours. Within 15 to 30 minutes of eating a snack or meal, do five or 10 minutes of light activity. Take the dog for a walk, climb stairs in your house or do some basic strength exercises.


:Sip green tea

You might love your lattes, but if you switch to green tea, not only will you get a healthy dose of disease-fighting compounds, you'll also cut body fat. In a study from The American Journal of Clinical Nutrition, people who drank a bottle of tea fortified with green tea extract every day for three months lost more body fat than people who drank black tea. Researchers at a health care lab in Tokyo believe disease-fighting antioxidants called catechins in green tea may help decrease body fat.


Friday, November 9, 2012

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Trauma in pregnancy

Trauma in Pregnancy remains the leading cause of non O. morbidity & Mort. accounting for 46 % of fatalities in pregnant women.
Since women remains active during preg it is reported that 6-7 % of them will have trauma.
The major cause of maternal death are the same as those in non pregnant; head injuries and hypovolemia.
Injury in pregnant women may be intentional or unintentional.
MVC & falls are most common cause of injury.
However, homicide and suicide accounts for 1/3 of cases.
In one study domestic violence occurred in at least 8-17 % of cases during pregnancy. Single kick to abdomen in late preg. is associated with abruption placentae and fetal loss.
In one series, 57% of the maternal deaths were due to homicides and 7% due to suicides.
Causes of traumatic injury roughly parallel those seen in the general population, blunt being more common.
10% of maternal deaths from trauma are due to head injury, like the general population.
Maternal death rate is not statistically different from the general matched population.
Trauma, however, does seem to raise the rate of fetal loss and placental abruption over baseline rates in pregnant population.

Physiological Changes During Pregnancy
Each system of the mother undergoes changes to compensate for the growing metabolic demand and load
of the new fetus.
The cardiovascular and hematopoetic changes include those noted above.
Additionally, there are increased amounts of thrombolytic factors present in the placenta, although systemic measurements of coagulation are normal.
The placental vascular system is exquisitely sensitive to circulating catacholamines which may result in intense vasoconstriction.
Maternal shock may result in 85% fetal mortality.

Cardiovascular
Total blood volume increases by 50%
Shock-like changes
Up to 20% acute and 30-35% gradual blood loss may show no sign of instability
Normal baseline heart rate is increased up by 10-15 bpm
Diastolic BP is decreased by 5-15 mmHg...

Injuries unique to pregnancy
Premature Contractions
Rarely progress to preterm delivery
Tocolysis is not proven in trauma.(1)

Abruptio Placentae
Different elastic properties in uterus & placenta “shearing”
3 % of minor trauma and upto 50 % in severe trauma

Uterine Rupture
Rare, 0.6 % of severe abdominal trauma (1)
Direct trauma after 12 wks of gestation
Prior Surgery (C/S or Myomec.) the risk

Maternal-Fetal Hemorrhage
Trimesters:T1 3%, T2 12%, T3 45%
4-5 X more common in injured pregnant women
Causes isoimmunization & fetal death
Kleihauer-Betke test - volume of fetal blood
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